Essential flexibility in the T-cell recognition of antigen.
basic_science · Level V
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- Record sourced from PubMed, PMID 8606766.
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Abstract
alpha beta T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.
Medical subject headings
- Antigens
- Receptors, Antigen, T-Cell
- T-Lymphocytes