Nonpolypoid adenomas and adenocarcinomas found in background mucosa of surgically resected colons.

Abstract

Nonpolypoid (depressed or flat) neoplasias are rarely seen in the colon and rectum. We previously reported their histogenesis and characteristics in patients with familial adenomatous polyposis (FAP), but their development in patients without FAP has not been studied systematically. Three hundred specimens of large intestinal mucosa surgically resected from patients with cancers or other diseases, excluding FAP, were examined with a dissecting microscope. The morphologic types, sizes, locations, and frequencies of detectable colorectal neoplasias, and their histologic features, were analyzed. A total of 297 adenomas (240 polypoid, 32 flat, and 25 depressed type) were obtained. Nonpolypoid adenomas were most frequently found in the transverse and descending colon. Almost all depressed adenomas (24 of 25; 96%) were less than 3 mm in greatest dimension and almost all flat adenomas (31 of 32; 96.9%) were less than 3.5 mm in greatest dimension. Three minute, nonpolypoid adenocarcinomas (mean size, 2.6 mm; range, 2.4-2.9 mm) were also detected, two of them already invaded the submucosal layer. Minute nonpolypoid type adenomas may be present in the background mucosa of patients without FAP. This study suggests that even minute nonpolypoid adenocarcinomas have an increased potential for endophytic growth.