Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies.
rct · Level II
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Abstract
In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose.
Medical subject headings
- Chloral Hydrate
- Procedural Sedation
- Hypnotics and Sedatives
- Midazolam
- Tomography, Emission-Computed, Single-Photon
- Tomography, X-Ray Computed