Synthesis and coupling reactions of alpha,alpha-dialkylated amino acids with nucleobase side chains.
basic_science · Level V
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- Record sourced from PubMed, PMID 8618834.
- Also identified by PMC identifier 40286.
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Abstract
Several di- and tripeptides containing protected purine (adenine) and pyrimidine (thymine) residues on their side chains were synthesized. The parent amino acids alpha, alpha-dialkylated in a symmetrical manner. An effective coupling procedure was developed for these sterically hindered amino acids: the fluoren-9-ylmethyloxycarbonyl-protected amino acid was dehydrated to its oxazolinone form, which was coupled in good yields with amino esters in hot tetrachloroethane.
Medical subject headings
- Adenine
- Amino Acids
- Thymine