Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8619556.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hel-N1 and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel-NI, Hel-N2, HuD, and HuC cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinction. Here we demonstrate that Hel-NI and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription-polymerase chain reaction.
Medical subject headings
- Carcinoma, Small Cell
- Lung Neoplasms
- Nerve Tissue Proteins
- RNA-Binding Proteins