Felbamate-associated fatal acute hepatic necrosis.
case_report · Level V
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- Record sourced from PubMed, PMID 8628501.
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Abstract
Thirty-six cases of hepatic toxicity associated with felbamate therapy have been collected by the Food and Drug Administration. Five patients died. We describe a case of massive acute hepatic necrosis and death within 40 days of initiation of felbamate therapy for a generalized tonic-clonic seizure disorder. We describe the clinical and histopathologic features.
Medical subject headings
- Anticonvulsants
- Chemical and Drug Induced Liver Injury
- Epilepsy, Tonic-Clonic
- Liver
- Propylene Glycols