Modification of rhythmical jaw movements by noxious pressure applied to the periosteum of the zygoma in decerebrate rabbits.

Abstract

The purpose of this study was to describe and quantify changes in the movement and EMG patterns caused by tonic noxious pressure on the periosteum of the zygoma during electrically induced rhythmic jaw movements in the decerebrate rabbit. Eight New Zealand rabbits were anesthetized with urethane. EMG electrodes were placed in the masseter and digastric muscles and a light was attached to the mandibular symphysis to track jaw movements. The animals were decerebrated and the anesthetic was discontinued. Rhythmic jaw movements were evoked by electrically stimulating the corticobulbar tracts (1-msec rectangular pulses, 50 Hz), in the absence and presence of tonic noxious pressure applied bilaterally to the zygomatic periosteum (range: 400-1500 kPa). The overall response to tonic noxious pressure was a statistically significant decrease in the frequency and amplitude of the rhythmic jaw movements and in the mandibular velocity during opening and closing. The slowing of the frequency was associated with a significant increase in the duration between muscle bursts. In those animals in which the jaw closing muscles were most active, there was a significant decrease in the area of the masseter muscle bursts during jaw closure. The changes in motor activity in response to the application of tonic noxious pressure are similar to those that have been reported for patients experiencing musculoskeletal pain, suggesting that pain modifies motor programs at the segmental level. Our data support the pain-adaptation model.