Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.
basic_science · Level V
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- Record sourced from PubMed, PMID 8633064.
- Also identified by PMC identifier 39535.
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Abstract
Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].
Medical subject headings
- Guanidines
- Nucleic Acid Conformation
- Oligoribonucleotides
- RNA