Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa.
case_control · Level III
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Abstract
Helicobacter pylori causes type B gastritis. It shows strong association with the development of gastric carcinoma. A plausible hypothesis for the missing link between H. pylori infection and gastric carcinogenesis involves oxygen free radical-induced DNA damage. To test this hypothesis, we compared the amount of 9-hydroxydeoxyguanosine, a marker for oxygen free radical-induced DNA damage, in the DNA of human gastric mucosa with and without H. pylori infection. Gastric antral biopsies were taken from pediatric patients and volunteers to select H. pylori-positive and H. pylori-negative specimens. The 8-hydroxydeoxyguanosine content of the gastric mucosal DNA was measured after H. pylori-positive and H. pylori-negative volunteers were identified. The increased level of oxidative DNA damage suggests the mechanistic link between H. pylori infection and gastric carcinoma.
Medical subject headings
- DNA
- DNA Damage
- Deoxyguanosine
- Gastric Mucosa
- Gastritis
- Helicobacter Infections
- Helicobacter pylori
- Reactive Oxygen Species