Crystal structure of a human TATA box-binding protein/TATA element complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 8643494.
- Also identified by PMC identifier 39370.
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Abstract
The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.
Medical subject headings
- DNA-Binding Proteins
- TATA Box
- Transcription Factors