Linkage of a gene for macular corneal dystrophy to chromosome 16.
other · Level V
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- Record sourced from PubMed, PMID 8644739.
- Also identified by PMC identifier 1914688.
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Abstract
Autosomal recessive macular corneal dystrophy (MCD) is a heterogeneous disorder leading to visual impairment. Sixteen American and Icelandic families (11 type I and 5 type II) were analyzed for linkage, by use of 208 polymorphic microsatellite markers. A significant maximum LOD score Zmax of 7.82 at a maximum recombination fraction (thetamax) of .06 was found with the 16q22 locus D16S518 for MCD type I. In addition, a peak LOD score of 2.50 at a recombination fraction of .00 was obtained for the MCD type II families, by use of the identical marker. These findings raise the possibility that MCD type II may be due to the same genetic locus that is involved in MCD type I.
Medical subject headings
- Chromosomes, Human, Pair 16
- Corneal Dystrophies, Hereditary
- Genetic Linkage