Reversible dementia and chorea in a young woman with the lupus anticoagulant.
case_report · Level V
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Abstract
A 22-year-old woman gradually developed depression, dementia, and chorea over an 8-month period. She fulfilled the criteria for the primary antiphospholipid antibody syndrome but not those for systemic lupus erythematosus. Her chorea and neurobehavioral deficits responded favorably to a regimen of prednisone, hydroxychloroquine, and aspirin. This appears to be the first report of a patient with a lupus anticoagulant and reversible dementia. The response to immunosuppressive therapy implies an antibody-mediated condition similar to Sydenham's chorea.
Medical subject headings
- Antiphospholipid Syndrome
- Aspirin
- Autoimmune Diseases
- Chorea
- Dementia
- Hydroxychloroquine
- Immunosuppressive Agents
- Lupus Coagulation Inhibitor
- Prednisone