Kinetics of self-assembling microtubules: an "inverse problem" in biochemistry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8650204.
- Also identified by PMC identifier 39173.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Experimental time series for a nonequilibrium reaction may in some cases contain sufficient data to determine a unique kinetic model for the reaction by a systematic mathematical analysis. As an example, a kinetic model for the self-assembly of microtubules is derived here from turbidity time series for solutions in which microtubules assemble. The model may be seen as a generalization of Oosawa's classical nucleation-polymerization model. It reproduces the experimental data with a four-stage nucleation process and a critical nucleus of 15 monomers.
Medical subject headings
- Microtubules