Intraoperative radiotherapy for pancreatic carcinoma. Experimental and clinical studies.
review · Level V
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Abstract
Intraoperative radiotherapy (IORT) is an innovative treatment approach that has been tested in several Phase I-II studies and small Phase III trials in patients with resectable and unresectable pancreatic cancer. The technical approach and dose guidelines for adjacent normal tissues have been established in a series of experiments using a large animal (canine) model. This article reviews the experimental and clinical studies of IORT in cancer of the pancreas.
Medical subject headings
- Pancreatic Neoplasms