Cellular immune mechanisms in myosin-induced myocarditis.
basic_science · Level V
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- Record sourced from PubMed, PMID 8682107.
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Abstract
Cardiac myosin-induced myocarditis proved to be a valuable virus-free murine model with which to investigate autoimmunological mechanisms in inflammatory heart disease. The disease was shown to be T cell-mediated. In this contribution the functional role of CD4 and CD8 molecules and the conditions that are required to make the cardiac tissue susceptible to an autoimmune attack are discussed.
Medical subject headings
- Autoimmune Diseases
- Immunity, Cellular
- Myocarditis
- Myosins