The beta 1-adrenoceptor as antigen: functional aspects.
basic_science · Level V
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Abstract
The sera of patients with myocarditis and idiopathic dilated cardiomyopathy contain agonistic autoantibodies that bind to the beta 1-adrenoceptor. These antibodies recognize epitopes on either the first or second extracellular loop of this receptor and exert in cultured neonatal rat heart myocytes a positive chronotropic effect. This effect is eliminated by beta 1-adrenoceptor blockade as well as by peptides corresponding to the first or second extracellular loop of the human beta 1-adrenoceptor. The antibodies realize their effects mainly via the beta-adrenoceptor-adenylate cyclase-protein kinase A cascade.
Medical subject headings
- Autoantibodies
- Cardiomyopathy, Dilated
- Epitopes
- Myocarditis
- Receptors, Adrenergic, alpha-1