Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8684460.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.
Medical subject headings
- CDC2-CDC28 Kinases
- Cell Cycle Proteins
- Cyclin-Dependent Kinases
- Cyclins
- Enzyme Inhibitors
- Microtubule-Associated Proteins
- Protein Serine-Threonine Kinases
- Tumor Suppressor Proteins