Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid.
basic_science · Level V
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Abstract
The effect of n-6 fatty acids, particularly gamma-linolenic acid (GLA), on the oxidase response and neutrophil priming by tumour necrosis factor alpha and interleukin 8 was studied in both normal volunteers and patients with obstructive jaundice. GLA inhibited the neutrophil respiratory burst at concentrations higher than 50 mummol/l, but abolished cytokine priming at concentrations as low as 1 mummol/l. Inhibition was not the result of either cytotoxicity to the neutrophils or alteration in cytosolic free calcium homoeostasis. It is concluded that GLA is a potential inhibitor of neutrophil priming by cytokines and of the oxidative response.
Medical subject headings
- Interleukin-8
- Neutrophils
- Respiratory Burst
- Tumor Necrosis Factor-alpha
- gamma-Linolenic Acid