Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.
basic_science · Level V
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- Record sourced from PubMed, PMID 8692865.
- Also identified by PMC identifier 39073.
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Abstract
Gadolinium(III) texaphyrin (Gd-tex2+) is representative of a new class of radiation sensitizers detectable by magnetic resonance imaging (MRI). This porphyrin-like complex has a high electron affinity [E1/2 (red.) approximately = -0.08 V versus normal hydrogen electrode] and forms a long-lived pi-radical cation upon exposure to hydrated electrons, reducing ketyl radicals, or superoxide ions. Consistent with these chemical findings, Gd-tex2+ was found to be an efficient radiation sensitizer in studies carried out with HT29 cells in in vitro as well as in in vivo single and multifraction irradiation studies with a murine mammary carcinoma model. Selective localization of Gd-tex2+ in tumors was confirmed by MRI scanning.
Medical subject headings
- Mammary Neoplasms, Experimental
- Metalloporphyrins
- Radiation-Sensitizing Agents
- Sarcoma, Experimental