Flumazenil: an unreliable antagonist in baclofen overdose.
case_report · Level V
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Abstract
We report a case of inadvertent overdose of baclofen given intrathecally resulting in coma. This was unresponsive to flumazenil and required supportive intensive therapy. With the increasing use of baclofen intrathecally for spasticity and its wide interpatient dose variability, there is a need to find a safe antagonist to baclofen for routine medical use.
Medical subject headings
- Antidotes
- Baclofen
- Flumazenil
- Muscle Relaxants, Central