Laparoscopic aortic replacement in the porcine model: a feasibility study in preparation for laparoscopically assisted abdominal aortic aneurysm repair in humans.

Abstract

Current laparoscopic vascular techniques have centered around aortofemoral bypass for the treatment of patients with aortic occlusive disease. However, the majority of aortic surgeries are performed for the treatment of aortic aneurysmal disease. With this mind, we undertook this study to assess the feasibility of laparoscopic aortic replacement in the porcine model in preparation for laparoscopically assisted abdominal aortic aneurysm (AAA) repair in humans. Twenty-three female pigs weighing between 35 and 40 kg underwent laparoscopic aortic dissection by either a transabdominal or retroperitoneal approach. The infrarenal aorta was laparoscopically dissected, isolated, and cross clamped. Then a custom designed cuffed polytetrafluoroethylene graft was inserted. After reestablishing and confirming distal flow, the animals were sacrificed. Fifteen functioning aortic grafts were placed in 21 animals who had the transabdominal approach. One functioning graft was placed in the retroperitoneal group. Complications included bladder, ureteral, inferior vena cava, renal vein, and aortic injuries. By the end of the study, the operative time was reduced from six to less than two hours; blood loss was reduced from 1,000 to 150 mL; and cross-clamping time was reduced from 60 to 15 minutes. In the porcine model, laparoscopic abdominal aortic replacement is associated with a significant learning curve. However, this method of repair is technically feasible and warrants further investigation in the treatment of AAA in humans.