Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8700895.
- Also identified by PMC identifier 39920.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The ganglionic cell type in which varicella-zoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein. VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system.
Medical subject headings
- Ganglia, Sympathetic
- Herpesvirus 3, Human
- Immediate-Early Proteins
- Trans-Activators
- Trigeminal Ganglion
- Viral Envelope Proteins
- Virus Latency