A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease.
case_control · Level III
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Abstract
We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.
Medical subject headings
- Alzheimer Disease
- Apolipoproteins E
- Genotype
- Mental Disorders