Peripheral blood stem cell transplantation in acute myeloid leukemia: the experience of the Bordeaux Group.

Abstract

Since our initial report of successful peripheral blood stem cell transplantation (PBSCT) in a patient with acute myeloid leukemia (AML), we have performed more than 300 PBSCTs; 49 of them were done for AML patients. PBSC mobilization (and collection) was influenced by the number of previous courses of chemotherapy and significantly increased when G-CSF was combined with chemotherapy for mobilization. Hematopoietic recovery (HR) was complete in every patient. The HR rate was influenced by the number of cells transplanted. Platelet recovery was significantly quicker for patients given G-CSF for mobilization. The outcome of patients transplanted in first or second remission was similar to that usually observed after bone marrow transplantation.