A pseudolikelihood approach to correcting for ascertainment bias in family studies.
other · Level V
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- Record sourced from PubMed, PMID 8751874.
- Also identified by PMC identifier 1914909.
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Abstract
The Cannings and Thompson approach to correcting for ascertainment bias in family studies is extended to settings with multiple ascertainment. The extension is based on maximizing a pseudolikelihood. Two approaches to computing standard errors for the maximum pseudolikelihood estimate are described. One is especially simple to compute, while the other is more generally applicable. Simulation experiments suggest that the standard-error computations can be quite accurate.
Medical subject headings
- Pedigree
- Selection Bias