Severe hyperchloriduria-hyperkaliuria: a new congenital renal tubular abnormality?

Meyburg, J; Mayatepek, E; Hoffmann, G F; Linderkamp, O; Seyberth, H W · J Pediatr · 1996

case_report · Level V

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Abstract

A female infant, aged 5 weeks, had metabolic alkalosis associated with severe electrolyte disturbances. In addition to findings typically seen in patients with Bartter syndrome or hyperprostaglandin E syndrome, she had massive urinary excretion of prostaglandins E2 and E-M, normal calcium metabolism, hyperphosphaturia, and severe hyperchloriduria and hyperkaliuria with limited response to indomethacin. These findings may represent a new congenital renal tubular abnormality.

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