Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
case_report · Level V
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Abstract
A worker in a polyvinyl chloride factory with rapidly progressive diffuse cutaneous scleroderma was treated with the humanized monoclonal antibody (Mab) CAMPATH-1H. Treatment was followed by rapid and substantial improvement in skin score, which was maintained during followup without additional therapy. The mode of action of CAMPATH-1H and its relationship to clinical improvement are discussed.
Medical subject headings
- Antibodies, Monoclonal
- Antibodies, Neoplasm
- Scleroderma, Systemic
- Skin Diseases