Long-range repression in the Drosophila embryo.
review · Level V
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- Record sourced from PubMed, PMID 8790326.
- Also identified by PMC identifier 38424.
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Abstract
Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types of gene regulation that are made possible by short- and long-range repressors.
Medical subject headings
- Drosophila
- Gene Expression Regulation, Developmental