Interleaflet clear space is reduced in the membrane of COP I and COP II-coated buds/vesicles.

Orci, L; Schekman, R; Perrelet, A · Proc Natl Acad Sci U S A · 1996

other · Level V

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Abstract

Intracellular transfers between membrane-bound compartments occur through vesicles that bud from a donor compartment to fuse subsequently with an acceptor membrane. We report that the membrane that delimits COP I or COP II-coated buds/vesicles from the endoplasmic reticulum and the Golgi complex has a thinner interleaflet clear space as compared with the surrounding, noncoated parental membrane. This change is compatible with a compositional change of the membrane bilayer during the budding process.

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