Glutathione deficiency as a complication of methylmalonic acidemia: response to high doses of ascorbate.
case_report · Level V
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- Record sourced from PubMed, PMID 8804337.
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Abstract
A 7-year-old boy with deficient activity of methylmalonyl coenzyme A mutase (mut-methylmalonic acidemia) was seen in severe metabolic crisis. After hemodialysis and clearance of toxic metabolites, severe lactic acidosis persisted with multiorgan failure. Glutathione deficiency was noted and high-dose ascorbate therapy (120 mg/kg) commenced. Glutathione deficiency may contribute to the lactic acidosis observed during decompensation in patients with methylmalonic acidemia.
Medical subject headings
- Amino Acid Metabolism, Inborn Errors
- Ascorbic Acid
- Glutathione
- Methylmalonic Acid