Compartment switching of WNT-2 expression in human breast tumors.
basic_science · Level V
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Abstract
WNT-2 is a secreted polypeptide with mitogenic effects in murine mammary epithelial cells, but its role in human cancer is unknown. Using RNase protection analysis of primary cell preparations and in situ hybridization analysis, we report that WNT-2 is expressed at low levels in normal human breast fibroblasts but not in epithelial cells. WNT-2 was found to be expressed at high levels in both the epithelium and stroma of 5 of 11 infiltrating carcinomas and 2 of 6 fibroadenomas. The high level of WNT-2 expression in tumor epithelium suggests that tumorigenesis may involve the ectopic expression of WNT-2 and the creation of an autocrine Wnt signaling loop.
Medical subject headings
- Breast
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Fibroadenoma
- Gene Expression Regulation, Neoplastic
- Neoplasm Proteins
- Proto-Oncogene Proteins