Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer.
basic_science · Level V
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Abstract
Progressive microsatellite changes in replication error positive (RER+) endometrium were used to reconstruct evolutionary stages of nonfamilial adenocarcinoma. RER+ putative endometrial precancers (atypical endometrial hyperplasias) progress to RER+ carcinomas, which retain some of the altered microsatellites acquired in earlier precursor stages. The RER+ phenotype may provide a specific marker for early-stage endometrial neoplasms that cannot be resolved by routine histopathology and may be a useful tool to stratify stages in the evolution of RER+ tumors.
Medical subject headings
- Adenocarcinoma
- Alleles
- DNA, Neoplasm
- Endometrial Neoplasms
- Microsatellite Repeats
- Precancerous Conditions
- Uterine Diseases