Bovine collagen induced systemic symptoms: antibody formation against bovine and human collagen.
case_report · Level V
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Abstract
We describe the first case of systemic symptoms after injection of bovine collagen and silicone polymers associated with antibodies to both native type I and II bovine and human collagen that varied with clinical features. Joint inflammation, edema at the injection site of bovine collagen implant and fever appeared 6 months after injection. Our patients history raises the question of whether the injection of animal derived collagen, particularly combined with silicone, induces or exacerbates autoimmune disease.
Medical subject headings
- Autoimmune Diseases
- Collagen
- Prostheses and Implants