Influence of carboxylate ions containing polymers on calcification: in vitro study.
basic_science · Level V
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Abstract
Calcification of implant or surrounding tissues represents an important complication of its function. The role of the molecular structure of a model hydrogel on the calcification is studied here in a simple in vitro, cell free system. The results show that-COO- containing polymers have an inhibitory effect on Ca2+ crystal formation. This process seems to be unspecific, because the polymers of different structure and origin have an inhibitory effect. However, its efficiency is related to a different extent of Ca2+ binding capacity of distinct polymers.
Medical subject headings
- Alginates
- Biocompatible Materials
- Calcinosis
- Gelatin