Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets.
basic_science · Level V
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Abstract
A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.
Medical subject headings
- Anti-Bacterial Agents
- Antibiotic Prophylaxis
- Endocarditis, Bacterial
- Gentamicins
- Heart Valve Prosthesis
- Postoperative Complications