Colonization of a calcium phosphate/elastin-solubilized peptide-collagen composite material by human osteoblasts.
basic_science · Level V
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Abstract
The evaluation of the suitability of a new biomaterial as a possible substitute for bone tissue is described here. This biomaterial is based on calcium phosphate particles linked to an artificial connective matrix, the elastin-solubilized peptides (ESP) associated with type I and III collagens. This work demonstrates the feasibility of shaping this composite material into discs, describes its microstructural characteristics, and evaluates its capacity as a substrate for the proliferation of human osteoblasts without loss of their phenotypic expression.
Medical subject headings
- Biocompatible Materials
- Collagen
- Durapatite
- Elastin
- Osteoblasts
- Peptide Fragments