Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module.
basic_science · Level V
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- Record sourced from PubMed, PMID 8855243.
- Also identified by PMC identifier 38218.
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Abstract
Fibronectin type III modules contain approximately 90 residues and are an extremely common building block of animal proteins. Despite containing a complex all-beta-sheet topology and eight prolines, the refolding of the 10th type III module of human fibronectin has been found to be very rapid, with native core packing, amide hydrogen bonding, and backbone conformation all recovered within 1 s at 5 degrees C. These observations indicate that this domain can overcome many structural characteristics often thought to slow the folding process.
Medical subject headings
- Fibronectins
- Protein Folding