Structure of a replication-terminator protein complexed with DNA.
basic_science · Level V
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- Record sourced from PubMed, PMID 8857533.
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Abstract
The crystal structure of the Escherichia coli replication-terminator protein (Tus) bound to terminus-site (Ter) DNA has been determined at 2.7 A resolution. The Tus protein folds into a previously undescribed architecture divided into two domains by a central basic cleft. This cleft accommodates locally deformed B-form Ter DNA and makes extensive contacts with the major groove, mainly through two interdomain beta-strands. The unusual structural features of this complex may explain how the replication fork is halted in only one direction.
Medical subject headings
- Bacterial Proteins
- DNA Replication
- DNA, Bacterial
- DNA-Binding Proteins
- Escherichia coli Proteins
- Nucleic Acid Conformation
- Protein Conformation