Methotrexate treatment of Wegener granulomatosis in children.
case_report · Level V
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- Record sourced from PubMed, PMID 8859270.
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Abstract
Wegener granulomatosis traditionally has been treated with glucocorticoids and cyclophosphamide. Both the disease and its treatments are associated with significant morbidity and mortality rates. There has been an effort to find effective but less toxic alternative treatments. We describe three children with Wegener granulomatosis who responded well to treatment with glucocorticoids and methotrexate, similar to a regimen used in adults.
Medical subject headings
- Anti-Inflammatory Agents
- Glucocorticoids
- Granulomatosis with Polyangiitis
- Methotrexate
- Prednisone