Suppression of TNF-alpha-induced apoptosis by NF-kappaB.
basic_science · Level V
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Abstract
Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IkappaBalpha (IkappaBalphaM). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappaB activation suppresses the signals for cell death.
Medical subject headings
- Apoptosis
- I-kappa B Proteins
- NF-kappa B
- Signal Transduction
- Tumor Necrosis Factor-alpha