Bleeding in a patient taking Lorenzo's oil: evidence for a vascular defect.
case_report · Level V
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- Record sourced from PubMed, PMID 8871463.
- Also identified by PMC identifier 2398367.
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Abstract
We describe a man with adrenoleukodystrophy receiving Lorenzo's oil (glycerol trioleate and glycerol trierucate) who developed purpura, petechiae, and bleeding. Bleeding time was markedly increased (>20 min), although he had only borderline thrombocytopenia (120 x 10(9)/1) and conventional platelet aggregation studies were normal (except for a borderline response to low concentration collagen), as were results using a new technique employing immobilised von Willebrand factor. Together these results suggest that bleeding in this man resulted from a defect in vascular wall function or in the interaction of platelets with the endothelium.
Medical subject headings
- Adrenoleukodystrophy
- Dietary Fats, Unsaturated
- Erucic Acids
- Hemorrhage
- Purpura
- Triolein