Regression of AIDS-related Kaposi's sarcoma during therapy with thalidomide.

Solèr, R A; Howard, M; Brink, N S; Gibb, D; Tedder, R S; Nadal, D · Clin Infect Dis · 1996

case_report · Level V

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Abstract

A 14-year-old girl with HIV infection and subcutaneous Kaposi's sarcoma (KS) received thalidomide therapy for oral ulcers, resulting in regression of KS lesions, disappearance of KS-associated herpesvirus (KSHV) DNA from blood, and reduced viral load in tumor tissue. Administration of grauntocyte colony-stimulating factor resulted in clinical exacerbation of KS and reappearance of KSHV DNA in blood.

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