Osteogenesis imperfecta and malignant hyperthermia. Is there a relationship?
case_report · Level V
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- Record sourced from PubMed, PMID 8882252.
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Abstract
We describe a patient with osteogenesis imperfecta who developed tachycardia, metabolic and respiratory acidosis (pH 7.14, PCO2 8.4 kPa, BE -8.5 mmol.l-1) and hyperthermia up to 40 degrees C during anaesthesia with barbiturates, fentanyl, pancuronium, and nitrous oxide. Malignant hyperthermia was suspected and the patient treated accordingly. Two years later the in-vitro contracture test for malignant hyperthermia was completely normal. We conclude that hypermetabolism in patients with osteogenesis imperfecta is due to unknown mechanisms other than malignant hyperthermia.
Medical subject headings
- Anesthesia, Intravenous
- Fever
- Intraoperative Complications
- Malignant Hyperthermia
- Osteogenesis Imperfecta