The N-end rule: functions, mysteries, uses.
review · Level V
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- Record sourced from PubMed, PMID 8901547.
- Also identified by PMC identifier 37957.
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Abstract
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.
Medical subject headings
- Amino Acid Sequence
- Models, Biological
- Models, Chemical
- Proteins
- Saccharomyces cerevisiae Proteins
- Ubiquitin-Protein Ligases