Cancer-associated retinopathy in a patient with endometrial cancer.

Abstract

We studied a case of unusual retinopathy in a 60-year-old woman. The patient developed bilateral retinopathy with iridocyclitis and vitreitis. Corticosteroid therapy could not prevent deterioration of visual acuity and field. The electroretinogram became nonrecordable, and fluorescein angiogram exhibited retinal pigment epithelium window defects, fluorescein stainings to the vascular walls, and narrowed arterioles. The patient underwent hysterectomy and lymphadenectomy for endometrial cancer in the corporis uteri. She was found to possess antibodies against retinal 34-kd protein, leading to a diagnosis of cancer-associated retinopathy. Cancer-associated retinopathy may occur in patients with endometrial cancer of the corporis uteri.