Hypothalamic-hypophyseal dysgenesis as a neuroimaging correlate of pituitary hormone deficiency in anophthalmia.

Brodsky, M C; Frindik, J P · Am J Ophthalmol · 1996

case_report · Level V

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Abstract

To document the association of neurohypophyseal dysgenesis with hypopituitarism in a child with primary bilateral anophthalmia. An infant with bilateral anophthalmia underwent magnetic resonance imaging and endocrinologic evaluation. Magnetic resonance imaging showed dysgenesis confined to the hypothalamus and hypophyseal stalk. Endocrinologic testing showed low serum cortisol and pituitary gonadotropin levels. Magnetic resonance imaging can help predict which children with anophthalmia will have endocrinologic deficiencies.

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