Heteromultimeric CLC chloride channels with novel properties.
basic_science · Level V
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- Record sourced from PubMed, PMID 8917596.
- Also identified by PMC identifier 24098.
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Abstract
The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.
Medical subject headings
- Chloride Channels
- Muscle Proteins
- Muscle, Skeletal
- Nerve Tissue Proteins