Vitamin C status and colonic neoplasia.

Abstract

A subnormal status of vitamin C has been associated with an increased risk for several malignant diseases and may play a causative role in their development. The aim of the present study was to investigate whether this occurs also in neoplasms of the colon. We have studied dietary intake and status of vitamin C in a consecutive group of patients with adenomatous colonic polyps (n = 31) and compared it with that of patients with no such history and a normal colonic mucosa, as confirmed by colonoscopy (n = 54). Dietary intake of this vitamin, as assessed by the dietary recall method, was similar in the two groups, as were the levels of vitamin C in plasma and leukocytes. There were no significant differences in intake of dietary fiber, fat, vitamin A, or calcium between the two groups. Lack of association between vitamin C intake or status and colonic polyps persisted after adjustment for potential confounders. We conclude that in this population, a deficient status of vitamin C is not an important factor in colonic neoplasia.