T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover.
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- Record sourced from PubMed, PMID 8929418.
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Abstract
Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8(+) T cell TRF length decreased but CD4(+) T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8(+) T cells, but not in CD4(+) T cells. These results are compatible with CD4(+) T cell decline in HIV-1 infection caused by interference with cell renewal.
Medical subject headings
- Acquired Immunodeficiency Syndrome
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- HIV Infections
- HIV-1
- Telomere