Tolerance of nicotinamide and carbogen with radiation therapy for glioblastoma.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 8940752.
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Abstract
Nineteen patients with glioblastoma were treated with nicotinamide and carbogen and radiotherapy. Eight patients did not complete the protocol because of hepatic toxicity from phenytoin/nicotinamide drug interactions, persistent nausea or vomiting with nicotinamide, intolerance of the carbogen breathing apparatus, or other reason. In addition, early radiation neurotoxicity appeared increased.
Medical subject headings
- Carbon Dioxide
- Glioblastoma
- Liver
- Niacinamide
- Oxygen